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Single-Dose Kinetics Predict Steady-State Concentrations of Imipramine and Desipramine

William Z. Potter, MD, PhD; Anthony P. Zavadil III, MD; Irwin J. Kopin, MD; Frederick K. Goodwin, MD
Arch Gen Psychiatry. 1980;37(3):314-320. doi:10.1001/archpsyc.1980.01780160084010.
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• Single-dose prediction of ultimate steady-state concentrations of tricyclic antidepressants at the outset of treatment can be a valuable therapeutic tool that has had only limited application. We demonstrate accurate steady-state predictions following both the tertiary amine, imipramine hydrochloride, and the secondary amine, desipramine hydrochloride, in a carefully monitored long-term treatment patient population. Results show that long-term treatment does not alter metabolism of either imipramine or desipramine. The relative merits of single-dose predictions using total and "abbreviated" areas under the curve and concentration at 24 hours are compared. These findings demonstrate that single-dose prediction can be used as a practical therapeutic, as well as, research tool.


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