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Prostaglandins, Platelets, and Schizophrenia

John Rotrosen, MD; Arthur D. Miller; Donna Mandio; L. J. Traficante, PhD; Samuel Gershon, MD
Arch Gen Psychiatry. 1980;37(9):1047-1054. doi:10.1001/archpsyc.1980.01780220085010.
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• Prostaglandin (PG) E, enhances formation of 3H-adenosine3',5'-cyclic monophosphate (3H-cAMP) in platelets pulse-labeled with 3H-adenine. This response was assessed as an index of receptor sensitivity and of PG function. Prostaglandin E1 lated 3H-cAMP accumulation in platelets from schizophrenics was significantly reduced compared with control subjects. Platelet incorporation of 3H-adenine and basal 3H-cAMP levels did not differ between groups. Psychotropic drugs added in vitro generally did not alter basal or PGE1-stimulated 3H-cAMP accumulation. We discuss the results in terms of the possible role of PGs in the etiopathology of schizophrenia and derivative implications for treatment.


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