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Brain Monoamine Oxidase Activity in Schizophrenics and Controls

Michael A. Reveley, MD, MRCPsych; Vivette Glover, MA, PhD; Merton Sandler, MD, FRCP, FRCPath; Ernest G. Spokes, MD, MRCP
Arch Gen Psychiatry. 1981;38(6):663-665. doi:10.1001/archpsyc.1981.01780310063006.
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• Postmortem samples of caudate nucleus and frontal cortex from schizophrenic, schizophrenic-like, and control subjects were examined for monoamine oxidase activity using dopamine, phenylethylamine, and 5-hydroxytryptamine as substrates. There were no significant differences between the diagnostic groups with any of the three substrates. Neither was there a difference between the sexes, nor a consistent relationship of enzyme activity to age.


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