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Familial Pattern and Transmission of Gilles de la Tourette Syndrome and Multiple Tics

David L. Pauls, PhD; Donald J. Cohen, MD; Raymond Heimbuch, MPhil; Jill Detlor, RN; Kenneth K. Kidd, PhD
Arch Gen Psychiatry. 1981;38(10):1091-1093. doi:10.1001/archpsyc.1981.01780350025002.
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• Fifty-two patients with Gilles de la Tourette syndrome (TS) diagnosed according to DSM-III criteria and/or their parents were interviewed regarding symptoms among family members. Occurrences of TS and multiple tics (MT) among first-degree relatives were distinguished to determine the familial patterns of the two diagnoses. Comparing these data with family data collected on a random national sample of patients with TS, we found no differences between the two samples. Each separately and both combined showed that (1) MT seems to be a mild form of TS; (2) both MT and TS are transmitted in the same families; (3) the sex difference is real and not an artifact of ascertainment; and (4) the sex difference is related to the transmitted susceptibility as a threshold effect. A specific genetic mechanism has not been identified.


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