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Clonidine and Haloperidol in Gilles de la Tourette Syndrome

Arthur K. Shapiro, MD; Elaine Shapiro, PhD
Arch Gen Psychiatry. 1981;38(10):1183-1184. doi:10.1001/archpsyc.1981.01780350117015.
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To the Editor.—  The article describing clinical experience with clonidine hydrochloride as an alternative to haloperidol for the treatment of Gilles de la Tourette syndrome (TS) (Archives 1980;37:1350-1357), as well as the genetic and biochemical studies emanating from the Yale group, is a substantial contribution to the literature. However, we believe that several issues raised in this article warrant discussion.Gilles de la Tourette syndrome is defined by the authors as a "severe neuropsychiatric syndrome of childhood onset and lifelong duration that consists of multiform motor and phonic tics and other behavioral and psychological symptoms." It is conceptualized as a neuropsychiatric dysfunction that affects the regulation of impulses, thoughts, motor activities, speech, and complex actions... a disorder of psychomotor inhibition with a more or less pervasive impact and with varied and individualistic symptom profiles ranging from chronic tics through disabling compulsions, irritability, and attentional and learning difficulties, as well as


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