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Clonidine and Gilles de la Tourette Syndrome

Richard Dorsey, MD
Arch Gen Psychiatry. 1981;38(10):1185. doi:10.1001/archpsyc.1981.01780350119017.
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To the Editor.—  In response to the recent article by Cohen et al (Archives 1980;37:1350-1357), I share my own experience with the use of clonidine hydrochloride for 12 patients seen in private practice. Several were discussed with Cohen's group, and one was cited as case 14.All 12 patients were referred to me because of unsatisfactory response to haloperidol. Ten came specifically for a trial of clonidine therapy. Eight had proven intolerance to one or more of haloperidol's side effects (most commonly impairment of concentration and alertness), while four had failed to achieve satisfactory symptom control.The patients ranged in age from 7 to 38 years at the time of the initial visit, with a median age of 14 years and a mean age of 18 years. Follow-up for this group ranges from two months to over two years. The dosages administered ranged from 0.3 to 0.6 mg of


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