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Fluphenazine vs Placebo in Patients With Remitted, Acute First-Episode Schizophrenia

John M. Kane, MD; Arthur Rifkin, MD; Frederic Quitkin, MD; Devdutt Nayak, MD; Jorge Ramos-Lorenzi, MD
Arch Gen Psychiatry. 1982;39(1):70-73. doi:10.1001/archpsyc.1982.04290010048009.
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• Twenty-eight patients who had recently recovered from an acute-onset, first-episode schizophrenic illness were randomly given fluphenazine hydrochloride or decanoate or placebo for a one-year period in a double-blind study. Seven of 17 patients (41%) receiving placebo experienced a psychotic relapse, whereas none of 11 drug-treated patients experienced a relapse. Eighteen (69%) of the 26 patients available for follow-up (mean interval, 3.5 years) experienced a second psychotic relapse either during the study or afterward, and 50% (14/28) of the original sample experienced a third episode.


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