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Stimulated Lymphocytes in Schizophrenia

Motoe Hirata-Hibi, MD; Susumu Higashi, MD; Takehiko Tachibana, MD; Nobuo Watanabe, MD
Arch Gen Psychiatry. 1982;39(1):82-87. doi:10.1001/archpsyc.1982.04290010058011.
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• This study examines the effect of neuroleptic medication on the distribution of the reported atypical lymphocytes of schizophrenia. The predominant atypical type in schizophrenia was termed the P-type atypical lymphocyte to differentiate the cell from other types of peripheral lymphocytes. Such P cells showed stimulated features: clear cytoplasmic basophilia and an irregularly shaped nucleus with a leptochromatic structure and occasionally one or two nucleoli, but the cell size ranged from small to large. P cells were found in all 42 schizophrenic patients examined and ranged from 5% to 45% of lymphocytes. Patients receiving neuroleptic medication had a lower mean percentage of P cells (17.8%) compared with patients not receivingneuroleptic medication (28.7%). The findings indicate that neuroleptic medication is not likely to be inducing the P-cell reaction.

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