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Cerebral Glucography With Positron Tomography:  Use in Normal Subjects and in Patients With Schizophrenia

Monte S. Buchsbaum, MD; David H. Ingvar, MD; Robert Kessler, MD; Robert N. Waters, MD; John Cappelletti; Daniël P. van Kammen, MD; A. Catherine King; Jeannette L. Johnson, MS; Ronald G. Manning, PhD; Richard W. Flynn, PhD; Lee S. Mann, MS; William E. Bunney Jr, MD; Louis Sokoloff, MD
Arch Gen Psychiatry. 1982;39(3):251-259. doi:10.1001/archpsyc.1982.04290030001001.
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• Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron-emission tomography in eight patients with schizophrenia who were not receiving medication and in six age-matched normal volunteers. Subjects sat in an acoustically treated, darkened room with eyes closed after injection of 3 to 5 mCi of deoxyglucose 18F. After uptake, seven to eight horizontal brain scans parallel to the canthomeatal line were done. Scans were treated digitally, with a 2.3-cm strip peeled off each slice and ratios to whole-slice activity computed. Patients with schizophrenia showed lower ratios in the frontal cortex, indicating relatively lower glucose use than normal control subjects; this was consistent with previously reported studies of regional cerebral blood flow. Patients also showed diminished ratios for a 2.3-cm square that was positioned over central gray-matter areas on the left but not on the right side. These findings are preliminary; issues of control of mental activity, brain structure identification, and biologic and anatomic heterogeneity of schizophrenia remain to be explored.

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