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Familial Transmission of DSM-III Borderline Personality Disorder

Armand W. Loranger, PhD; John M. Oldham, MD; Elaine H. Tulis, PhD
Arch Gen Psychiatry. 1982;39(7):795-799. doi:10.1001/archpsyc.1982.04290070031007.
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• A comparison was made of the types of mental disorders occurring in the first-degree relatives of 83 female patients with DSM-III borderline personality disorder, 100 female patients with DSM-III schizophrenia, and 100 female patients with DSM-III bipolar disorder. Diagnosis of the relatives was made independently by two clinicians who were blind to the diagnosis of the probands. The relative of a borderline patient was about ten times more likely to have been treated for a borderline or borderlinelike personality disorder than was the relative of a schizophrenic or bipolar patient. The borderline patients' relatives were also treated for more unipolar depression than the schizophrenics' relatives. However, the relatives of the borderline patients did not have a higher morbid risk for treated mania or schizophrenia than that usually reported for the population at large.


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