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Induction of Mania-Reply

Jerry L. Lewis, MD; George Winokur, MD
Arch Gen Psychiatry. 1983;40(2):224. doi:10.1001/archpsyc.1983.01790020122017.
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In Reply.—  Dr Kocsis raised several points about our recent article that are worth discussing. The design that he suggests obviously is ideal, but a naturalistic evaluation can often be contributory. We undertook to find a group of patients with unequivocally bipolar disease who had not received treatment in one of their contacts with the Iowa Psychiatric Hospital, Iowa City. This was accomplished by identifying patients with bipolar disease who had had multiple admissions and who on one or more of those admissions had not received treatment.Dr Kocsis indicated that he would like to have data on the patients' length of hospitalization and the number of their previous episodes of mania. TheLength of Hospitalization and Previous Episodes of Mania in Patients With Bipolar Illness Treatment Regimen* Total No. of Admissions Patients Admitted With Previous Episodes of Mania, No. (%) Mean Length of Hospitalization, mo Untreated controls 32 14(37) 1.09 TCAs plus


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