Article |

Study of Gluten Effect in Schizophrenia

Man Mohan Singh, MD; Stanley R. Kay, PhD
Arch Gen Psychiatry. 1983;40(3):345. doi:10.1001/archpsyc.1983.01790030115016.
Text Size: A A A
Published online

To the Editor.—  The study of the effects of gluten on schizophrenics that was reported by Storms et al (Archives 1982;39:323-327) was scientifically weak and did not provide an adequate basis for rejection of the hypothesis being tested. Its conclusions were predicated on the fallacy that failure to reject the null hypothesis is equivalent to its confirmation, thus violating Fisher's inference model in which the two logical alternatives are "reject" and "inconclusive."1 Statisticians have long stressed this point, warning that a methodologically weak study—for example, one with few subjects, little homogeneity of variance, and measures of low reliability—increases the risk of a type II error.The adequacy of the experiment used to test the null hypothesis that "gluten has no effect on schizophrenics" can be directly measured by calculating its power value. Using Cohen's methods,2 we find the power value of this study (two groups of 13 subjects


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.