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Psychiatric Diagnosis and Risk for Tardive Dyskinesia

Badri J. Hamra, MD; Henry A. Nasrallah, MD; John Clancy, MD; Richard Finn, MD
Arch Gen Psychiatry. 1983;40(3):346-347. doi:10.1001/archpsyc.1983.01790030116019.
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To the Editor.—  Risk factors for tardive dyskinesia continue to be a controversial issue, and factors like age, sex, duration of treatment with neuroleptics, and type of treatment have been the focus of most research in this area. Little attention has been paid to the role of psychiatric diagnosis in predisposing for this syndrome. Tardive dyskinesia has been largely associated with schizophrenic disorders. Some authors suggested that patients with affective disorders may be at a high risk for tardive dyskinesia.1,2 Recently, in a study of psychiatric outpatients receiving long-term treatment with neuroleptics (>1 year), Mukherjee et al reported a considerably high incidence of tardive dyskinesia in a population in which half the patients did not meet diagnostic criteria for schizophrenia or schizoaffective disorder.3 The role of psychiatric diagnosis in tardive dyskinesia deserves more study.We recently completed a study of risk factors for tardive dyskinesia in a university

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