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Clozapine and Tardive Dyskinesia-Reply

Dilip V. Jeste, MD; Richard Jed Wyatt, MD
Arch Gen Psychiatry. 1983;40(3):347-348. doi:10.1001/archpsyc.1983.01790030117021.
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In Reply.—  Dr Singer questioned our method of analyzing treatment studies of TD. He specifically mentioned the issues of combining data from open and double-blind studies, using conventional statistics, and not identifying patients with complete remission. Yet, a careful reading of our article shows that data from double-blind and open studies were not combined. Not only were data from the two types of studies presented separately (in Table 1 and Fig 2), but they were also analyzed independently. Because of the shortcomings of conventional univariate comparisons, we used the statistical technique of simultaneous confidence intervals, which took into account possible type I errors resulting from multiple comparisons. Although it would have been helpful to know how many patients had recovered completely, few studies identify patients with complete remission, so such an analysis would have been difficult. The relevance of distinguishing between orofacial and limb dyskinesias is unclear.1,2 With many drugs, the


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