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A Naturalistic Assessment of the Motor Activity of Hyperactive Boys:  II. Stimulant Drug Effects

Linda J. Porrino, PhD; Judith L. Rapoport, MD; David Behar, MD; Deborah R. Ismond, MA; William E. Bunney Jr, MD
Arch Gen Psychiatry. 1983;40(6):688-693. doi:10.1001/archpsyc.1983.04390010098013.
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• Twenty-four-hour motor activity was assessed in a naturalistic setting in 12 hyperactive boys for four weeks (672 consecutive hours). Dextroamphetamine, 15 mg/day, or placebo was administered on alternate weeks, using a double-blind ABAB design. When the boys received dextroamphetamine, motor activity was significantly decreased for about eight hours after drug administration. This decrease was followed by a period of slight but significant increases in activity ("rebound"). Dextroamphetamine decreased activity most strikingly during structured classroom activity; during physical education, however, there was a significant drug-induced increase in motor activity.

(Arch Gen Psychiatry 1983;40:688-693)

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