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Article |

Altered P300 Topography in Schizophrenia

Ron Morstyn, MB, BS; Frank H. Duffy, MD; Robert W. McCarley, MD
Arch Gen Psychiatry. 1983;40(7):729-734. doi:10.1001/archpsyc.1983.01790060027003.
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• The spatiotemporal evolution of the P300 waveform was topographically mapped in a group of ten male chronic schizophrenics, using the technique of brain electrical activity mapping. Group-average P300 waveforms were constructed for the schizophrenic group and a group of matched controls. The control group's P300 showed a concentric development about a maximum in the centroparietal area, slightly displaced toward the left. In contrast, the schizophrenic group's P300 maximum was more anterior and to the right, with a deficiency in left temporal activity. Using the technique of significance probability mapping, it was demonstrated that the maximum between-group difference was localized to the left-middle and posterior temporal regions, where the schizophrenic group was deficient in activity.


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