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Low-Dose Neuroleptic Treatment of Outpatient Schizophrenics:  I. Preliminary Results for Relapse Rates

John M. Kane, MD; Arthur Rifkin, MD; Margaret Woerner, PhD; Gerard Reardon, MSW; Stavros Sarantakos, MD; David Schiebel, MD; Jorge Ramos-Lorenzi, MD
Arch Gen Psychiatry. 1983;40(8):893-896. doi:10.1001/archpsyc.1983.01790070083010.
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• In an attempt to begin to establish minimum effective dosage requirements for the maintenance treatment of schizophrenia, we undertook a double-blind comparison of low-dose fluphenazine decanoate (1.25 to 5.0 mg/2 wk) with the standard-dose regimen (12.5 to 50.0 mg/2 wk) in outpatient schizophrenics. For the first 126 patients studied, cumulative relapse rates at one year for the low dose were 56% and for the standard dose 7%, a significant difference. Despite the fact that very little dyskinetic symptomatology developed in the sample as a whole, the low-dose treatment appeared to have a significant advantage in producing fewer early signs of tardive dyskinesia. Severity of relapse and total cumulative dosage were also considered.

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