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LSD and Schizophrenia

Karl E. C. Weaver, MD
Arch Gen Psychiatry. 1984;41(6):631. doi:10.1001/archpsyc.1984.01790170105013.
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To the Editor.—  Vardy and Kay,1 reporting on LSD and schizophrenia, have addressed a significant issue for those attempting to define the nature and etiology of schizophrenic illnesses. The role of LSD and other hallucinogens, dopamine, and other amines (endogenous or exogenous) in functional psychoses still remains to be clarified. There has been dispute as to whether intoxication with LSD is a good model for schizophrenic psychosis (with the predominance of opinion being that it is not), and uncertainty as to the relative role of monoaminergic pathways in schizophrenic illness. With respect to LSD (which is clearly active in serotoninergic systems2) and serotoninergic activity in schizophrenics, at least eight studies have suggested serotoninergic abnormalities in schizophrenia.3-8 The conclusion reached by Vardy and Kay was that, in most respects, their patients who had LSD-induced psychosis could not be significantly differentiated from control schizophrenics.1 There are problems with


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