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Possible Interaction Between Phenelzine and Amantadine

Robert A. Jack, MD; David G. Daniel, MD
Arch Gen Psychiatry. 1984;41(7):726. doi:10.1001/archpsyc.1984.01790180096021.
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To the Editor.—  Monoamine oxidase inhibitors (MAOIs) are being used increasingly as antidepressants. Although the risk of serious adverse reactions such as hypertension have probably been overstated, the use of MAOIs requires attention to dietary and drug interaction factors.1'3 Amantadine hydrochloride is a dopaminergic agent frequently used as an adjunctive treatment in Parkinson's disease. It has also been used to combat the parkinsonian side effects of neuroleptics. This may be the first reported case of an adverse interaction between amantadine and an MAOI.

Report of a Case.—  A 49-year-old woman was transferred to a university hospital after an eight-day hospitalization at a private psychiatric facility in another city. At the time of transfer, she was taking thiothixene hydrochloride (5 mg/day), doxepin hydrochloride (175 mg/day), benztropine mesylate (5 mg/day), and flurazepam hydrochloride (30 mg at bedtime). An agitated delirium was suspected, and administration of her medications was discontinued for several


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