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August 1984, Vol 41, No. 8 >
Article | August 1984

l-Deprenyl in Atypical Depressives

Frederic M. Quitkin, MD; Michael R. Liebowitz, MD; Jonathan W. Stewart, MD; Patrick J. McGrath, MD; Wilma Harrison, MD; Judith G. Rabkin, PhD; Jeffrey Markowitz, MPH; Sharon O. Davies, RN
Arch Gen Psychiatry. 1984;41(8):777-781. doi:10.1001/archpsyc.1984.01790190051006.
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• We investigated the antidepressant efficacy of l-deprenyl (selegiline), a selective monoamine oxidase B inhibitor (MAOI), in a six-week open trial of 17 patients with atypical depression. Such patients have previously been shown to benefit from nonselective MAOIs such as phenelzine sulfate. Ten patients (59%) responded to l-deprenyl, but nine required dosages above the 10 to 20 mg/day used in previous investigations. l-Deprenyl was superior to six weeks of placebo administered to diagnostically similar patients in a separate double-blind study. In contrast with previous findings with phenelzine, responders to l-deprenyl differed from nonresponders by having lower baseline anxiety ratings. Even at high dosages, there appeared to be fewer side effects with l-deprenyl than with nonselective MAOIs.

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