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Trazodone and Cocaine Abuse

Gary W. Small, MD; John J. Purcell, MD
Arch Gen Psychiatry. 1985;42(5):524. doi:10.1001/archpsyc.1985.01790280106014.
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To the Editor.—  We read with interest the study by Rowbotham et al,1 "Trazodone-Oral Cocaine Interactions," and report herein a case in which trazodone proved to be useful in the treatment of cocaine withdrawal.

Report of a Case.—  A 32-year-old attorney had a three-year history of cocaine abuse. His use pattern was characterized by weekend binges of 2 to 5 g of cocaine administered intranasally. To support his habit, he drew on his savings account, unbeknownst to his wife. On Mondays and Tuesdays following the weekend, fatigue, poor concentration, and anhedonia disrupted his work performance. Other midweek symptoms of depression included feelings of sadness, impaired sleep, and agitation. During the three years of binging, the patient gained approximately 4 kg, which was attributed to an increased midweek appetite. Other drug use included nightly marijuana to help with his early insomnia as well as an estimated 360 to 450 mL

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