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Selection of Neuroleptic Dosage

Martin H. Teicher, MD, PhD; Ross J. Baldessarini, MD
Arch Gen Psychiatry. 1985;42(6):636-637. doi:10.1001/archpsyc.1985.01790290118019.
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To the Editor.—  There continues to be a lack of quantitative data to guide the selection of appropriate doses of neuroleptic agents. Such information would be particularly useful for longterm treatment of chronically psychotic patients to minimize the risk ofDose-Effect Relationship for Fluphenazine Decanoate in the Treatment of Schizophrenia for One Year Study, yr Dosage Mean No. of Range, Dosage, Relapse Dropout Success Subjects mg/2 wk mg/2 wk* Rate, %† Rate, %‡ Rate, %§ Hogarty et al, 1 1979 55 12.5-125 41 35.1 Marder et al, 2 1984 22 25-50 36 20.2 22.7 62 Rifkin et al, 3 1977 19 12.5-50 31 5.3 42.1 53 Kane et al, 4,5 1983, 1984 64 12.5-50 31 7.0 Marder et al, 2 1984 28 5-10 22.4 7.1 72 Kane et al, 5 1984 36 2.5-10 20.0 Kane et al, 4, 5 1983, 1984 62 1.25-5 56.0 Hogarty et al, 6 1976 41 67.4 4.7 32 Rifkin et al, 3 1977 19


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