0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Interpretation of Plasma Haloperidol Concentrations

Darrell G. Kirch, MD; Llewellyn B. Bigelow, MD; Richard J. Wyatt, MD
Arch Gen Psychiatry. 1985;42(8):838-839. doi:10.1001/archpsyc.1985.01790310106016.
Text Size: A A A
Published online

To the Editor.—  The recent study by Smith et al1 regarding plasma haloperidol concentrations and clinical response addressed an important issue in the treatment of schizophrenia. Their statistical analysis of the clinical data, however, illustrates the complexities involved in balancing mathematical rigor against the reasonable interpretation of clinical observations.The authors assumed that the neuroleptic-induced course of clinical improvement in symptoms of psychosis is linear and used this assumption to "estimate" Basic Psychiatric Research Scale (BPRS) scores for patients on days 0 and 24 of treatment. Clinical experience, however, indicates that in many patients response is "nonlinear," with a frequently observed pattern being one of more rapid improvement early in treatment followed by a more gradual phase. Furthermore, the linear model of the relationship of improvement vs time would, if extended, produce either a negative rating in the case of a patient whose condition is improving or a

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();