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Article |

Stimulant Therapy of 'Adult Hyperactivity'

Paul H. Wender, MD; Fred W. Reimherr, MD; David R. Wood, MD
Arch Gen Psychiatry. 1985;42(8):840. doi:10.1001/archpsyc.1985.01790310108018.
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To the Editor.—  Mattes et al1 published data that suggested that stimulant medication is ineffective in relieving the symptoms of attention deficit disorder, residual type (ADDRT, or "adult hyperactivity"). Their findings are in striking contrast with our findings using methylphenidate,2 pemoline,3 pargyline,4 and deprenyl,5 and a replication with methylphenidate.6 An examination of the article by Mattes et al1 and a personal communication offer a possible explanation to account for their apparent failure to replicate our findings. Their subjects differed from ours in an important aspect: their scores on the Parents' Rating Scale (PRS), which is a measure of childhood hyperactivity. In their study, the mean scores for ADD with hyperactivity and ADD without hyperactivity were 10.7 and 6.7, respectively; in contrast, we found that only subjects with scores of 12 or higher (the 95th percentile or higher) showed a therapeutic response. Only seven


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