We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Tardive Dyskinesia and Current Dose of Neuroleptic Drugs

T. Kolakowska, MD; A. O. Williams, MD; M. Ardern, MD
Arch Gen Psychiatry. 1985;42(9):925. doi:10.1001/archpsyc.1985.01790320097014.
Text Size: A A A
Published online


To the Editor.—  The reported prevalence of tardive dyskinesia (TD)—abnormal involuntary movements that develop during chronic treatment with neuroleptic drugs—varies widely, and the data on risk factors, especially among younger patients, are contradictory.1Though these drugs themselves are known to suppress TD, the current doses of neuroleptics have received relatively little attention in the actual epidemiological studies. The results of our recent study2 illustrate how this factor may affect the findings.

Patients and Methods.—  The sample consisted of 68 patients with schizophrenic or schizoaffective illness who were from 22 to 59 years of age (73% were under 40 years of age). All were receiving long-term treatment with neuroleptic drugs, most of them with fluphenazine decanoate or flupentixol decanoate. The current dose, expressed in equivalents of fluphenazine decanoate, ranged from 4.1 to 250 mg/week, and in all but two subjects it was kept constant for at least two months


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.