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Apomorphine's Antipsychotic Activity

Martin H. Schaffer, MD; John M. Davis, MD; Carol A. Tamminga, MD
Arch Gen Psychiatry. 1985;42(9):927. doi:10.1001/archpsyc.1985.01790320099017.
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To the Editor.—  Some controversy has developed recently over the antipsychotic efficacy of apomorphine in schizophrenic psychosis, including an article by Levy et al1 in the Archives.2 It is our opinion that a definitive answer to this question requires a broader experimental approach than that attempted by the investigators in either of these groups. Previously, Corsini and co-workers3,4 reported apomorphine's marked antipsychotic action when given in a dose of 1 mg subcutaneously to a group of unmedicated schizoaffective patients. Tamminga et al,5 in a double-blind placebocontrolled study, showed an equally dramatic effect of a 3-mg subcutaneous dose given to a group of chronic schizophrenic and schizoaffective subjects who were maintained on a neuroleptic regimen.5Those drug trials reporting antipsychotic activity of apomorphine in a controlled design are characterized by at least two features. First, a range of apomorphine doses, including high levels, were used in the

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