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Clomipramine Treatment of Childhood Obsessive-Compulsive Disorder:  A Double-blind Controlled Study

Martine F. Flament, MD; Judith L. Rapoport, MD; Carol J. Berg, MA; Walter Sceery, MSW; Clinton Kilts, PhD; Britt Mellström, PhD; Markku Linnoila, MD, PhD
Arch Gen Psychiatry. 1985;42(10):977-983. doi:10.1001/archpsyc.1985.01790330057007.
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• Nineteen children (mean [±SD] age, 14.5±2.3 years) with severe, primary obsessive-compulsive disorder completed a ten-week, double-blind, controlled trial of clomipramine hydrochloride (mean dosage, 141 mg/day) or placebo, each of which was administered for five weeks. Half of the subjects had not responded to previous treatment with other tricyclic antidepressants. There was a significant improvement in observed and self-reported obsessions and compulsions that was independent of the presence of depressive symptoms at baseline. Improvement in obsessive-compulsive symptoms did not correlate significantly with plasma concentrations of the drug or its metabolites. Clomipramine appears to be effective in the treatment of children with obsessive-compulsive disorder and the treatment seems to be independent of an antidepressant effect.


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