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Cerebral Ventricular Enlargement in Schizophrenia:  A Preliminary Follow-up Study

Henry A. Nasrallah, MD; Stephen C. Olson, MD; Mona McCalley-Whitters, BSN; Suzanne Chapman, BSN; Charles G. Jacoby, MD
Arch Gen Psychiatry. 1986;43(2):157-159. doi:10.1001/archpsyc.1986.01800020067008.
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• Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized.


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