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Correction and Amplification: Cortisol Response to 5-HTP

Herbert Y. Meltzer, MD; Brinda Umberköman-Wiita, PhD; Alan G. Robertson, MD; Betty Jo Tricou, MD; Martin Lowy, PhD
Arch Gen Psychiatry. 1986;43(8):815. doi:10.1001/archpsyc.1986.01800080101015.
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ABSTRACT

To the Editor.—  The data analysis in our article "Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: I. Enhanced Response in Depression and Mania" (ARCHIVES, 1984;41:366-374), entailed some errors that could affect our stated conclusions. We wish to correct the record, clarify some details of the methodology, and report a reanalysis of the corrected data and the consequent confirmation of our original hypothesis.Studies were carried out, in most instances, while the patients were in the second or later weeks of hospitalization or the drug-free state, which occurred during the third to seventh day of hospitalization in a few subjects who were believed to be drug-free before admission. We subsequently found that three of these subjects had received psychotropic drugs within the seven days before our study. TheseTable 1.—Area Under the Curve With Baseline Covaried Diagnosis Protocol, μg/dL (nmol/L)/N Placebo* 5-Hydroxytryptophan* Normal controls 59.1 ±5.0 (1632±138)/13

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