Article |

Tricyclic Antidepressant Washout Effects on Cerebrospinal Fluid and Urinary Monoamine and Metabolites

Stephen H. Koslow, PhD; James W. Maas, MD; John M. Davis, MD; Israel Hanin, PhD; Javaid Javaid, PhD; Charles L. Bowden, MD
Arch Gen Psychiatry. 1986;43(10):1012-1013. doi:10.1001/archpsyc.1986.01800100106014.
Text Size: A A A
Published online

To the Editor.—  Our previous publication on cerebrospinal fluid (CSF) and urinary concentrations of biogenic amines and metabolites in depression reported higher concentrations in many of these measures relative to the concentrations measured from samples collected from age- and sexmatched normal healthy controls.1 The possibility exists that these higher concentrations in depressed subjects are due to an inadequate drug washout period before sample collection. This may be especially true in light of the publication by Charney et al2 that reported a rebound or increase in concentrations of plasma and urinary 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) following withdrawal of tricyclic antidepressants.2

Patients and Methods.—  On intake into this study, all medications were withdrawn and information regarding medication usage during the current illness was obtained from all subjects and recorded on a medication review form. Drug class (eg, antidepressant, neuroleptic, anxiolytics, sedatives), specific generic information, and time of discontinuation of medication(s)


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.