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The Utility of the Dexamethasone Suppression Test-Reply

George W. Arana, MD; Martin H. Teicher, MD, PhD; Ross J. Baldessarini, MD
Arch Gen Psychiatry. 1987;44(1):95-96. doi:10.1001/archpsyc.1987.01800130107018.
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In Reply.—  In reflecting on correspondence and conversations following our recent review of the possible utility of the dexamethasone suppression test (DST) in psychiatry, we wish to make the following remarks and `amplifications. Certain evaluations pooled data from several studies to test for interesting trends by the use of ϰ2 statistics.1 Janicak et al2 recommended the use of a more conservative ϰ2 procedure developed by Mantel and Haenszel.3 We adapted their approach for use with a microcomputer and incorporated Yates' correction for small samples (the program is available from M.H.T.). The method computes a total ϰ2 statistic by accumulating data from contingency tables arising from each study and decomposes this overall value into a ϰ2 statistic of association testing the main effect, as influenced by the consistency of results across studies, as well as a statistic (ϰ2 for homogeneity) testing the consistency

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