Article |

Prolonged Pharmacologic Activity of Neuroleptic Drugs

John W. Hubbard, PhD; Derek Ganes, MSc; Kamal K. Midha, DSc
Arch Gen Psychiatry. 1987;44(1):99-100. doi:10.1001/archpsyc.1987.01800130111024.
Text Size: A A A
Published online

To the Editor.—  Campbell and Baldessarini1 described an experiment in which they administered moderatesingle doses of haloperidol to rats and found that the behavioral response to the dopamine agonist apomorphine was reduced significantly for at least one month. They commented that the plasma elimination half-life values of neuroleptic drugs are usually reported in the range of 20 to 40 hours, whereas the apparent half-life for recovery of normal response to apomorphine was 12.8 days. Moreover, Sedval and colleagues2 also showed a lack of concordance between dopamine D2 receptor occupancy in the brains of schizophrenics and plasma haloperidol levels following the withdrawal of the drug.

Subjects and Methods.—  Recently, we measured levels of haloperidol and reduced haloperidol in the plasma of healthy volunteers after single oral doses of 5 mg of haloperidol. It is standard practice in single-dose pharmacokinetic studies to follow plasma levels for three to


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.