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Marfan's Syndrome and Schizophrenia: A Case Report

John Romano, MD
Arch Gen Psychiatry. 1987;44(2):190-192. doi:10.1001/archpsyc.1987.01800140102017.
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To the Editor.—  Study and care of a patient with unmistakable evidence of Marfan's syndrome and schizophrenia led us to inquire into the association between these two conditions. We were aware that homocystinuria, an autosomal recessive trait, is often associated with mental retardation and has been noted to be associated with schizophrenia.1,2 However, a recent, detailed study of cognitive and psychiatric features of 68 patients with homocystinuria did not include schizophrenic patients.3In our search, we found occasional reference to borderline or limited intelligence, but one must remember that it was not until 19621 that homocystinuria was differentiated from Marfan's syndrome. We did find a case history of a 33-year-old woman hospitalized in a psychiatric ward because of schizophrenia.4 She is said to have had typical signs of arachnodactyly and bilateral dislocation of the lens, as well as roentgenographic evidence of an elongated and markedly dilated

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