Article |

The Physiology of Cocaine Craving and 'Crashing'

Charles A. Dackis, MD; Mark S. Gold, MD; Donald R. Sweeney, MD, PhD
Arch Gen Psychiatry. 1987;44(3):298-299. doi:10.1001/archpsyc.1987.01800150122018.
Text Size: A A A
Published online

To the Editor.—  In their article on abstinence symptomatology in cocaine abusers, Gawin and Kleber1 describe the cocaine "crashing" syndrome and other more protracted clinical manifestations of cocaine abstinence. They propose the term neuroadaptation for cocaine withdrawal, "if a physiologic basis for phase 2 symptoms is substantiated." We have already described crashing and other symptoms of cocaine withdrawal, hypothesized a physiological mechanism, and developed a specific pharmacotherapy,2 and we believe that our previously reported research and new data support the findings by Gawin and Kleber.Our hypothesis states that symptoms of cocaine withdrawal and cocaine craving result largely from dopamine depletion.2,3 Cocaine withdrawal symptoms, such as hypersomnia, anergia, hyperphagia, depression, and psychomotor retardation, are consistent with dopamine depletion since they are commonly seen after neuroleptic treatment and are found in Parkinson's disease. Our hypothesis is primarily supported by the finding of hyperprolactinemia in human cocaine abusers,4


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.