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No D2 Receptor Increase in PET Study of Schizophrenia

Lars Farde, MD; Frits-Axel Wiesel, MD; HÅkan Hall, PhD; Christer Halldin, PhD; Sharon Stone-Elander ,; Göran Sedvall, MD
Arch Gen Psychiatry. 1987;44(7):671-672. doi:10.1001/archpsyc.1987.01800190091013.
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To the Editor.—  Densities of D2 dopamine receptors in postmortem brain tissue from schizophrenic patients have been found to be higher than those in control brains.1,2 The pathophysiologic significance of this finding has been questioned, since elevated receptor densities may be caused by neuroleptic treatment.3 It is now possible to examine D2 dopamine receptor binding in the brains of living human subjects by means of new brain-imaging techniques and radiolabeled receptor ligands. Using a gamma camera and 77Br-Bromospiperone, Crawley et al4 reported evidence of a slight increase in D2 dopamine receptors in a group of schizophrenic patients. Using positron emission tomography (PET) and 11CN-Methylspiperone, Wong et al5 recently reported a twofold to threefold elevation of D2 dopamine receptor densities in the major basal ganglia of ten drug-naive and five previously treated schizophrenic patients. We previously used PET and

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