We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Elevation of Plasma Homovanillic Acid Level Can Be Detected Within Four Hours After Initiation of Haloperidol Treatment

R. Davila, PhD; M. ZUMARRAGA, MA; K. Perea, MD; I. Andia, MA; Arnold J. Friedhoff, MD
Arch Gen Psychiatry. 1987;44(9):837-838. doi:10.1001/archpsyc.1987.01800210089014.
Text Size: A A A
Published online


To the Editor.—  The increase in homovanillic acid (HVA) concentration in rat plasma occurring after treatment with neuroleptic drugs has been found to be largely of central nervous system origin,1 although basal levels derive from both the periphery and the central nervous system.2 The findings on the effect of neuroleptic drugs on plasma HVA level in humans have not been entirely consistent. Pickar et al3 failed to demonstrate an acute neuroleptic drug-induced increase in plasma HVA level in schizophrenic patients, and Davis et al4 originally were unable to detect this effect in subjects studied six hours after treatment. Recently, this latter group reported that an increase did occur 24 hours after treatment.5 They administered haloperidol intramuscularly at 11 AM (0.2 mg/kg) and later, at 6 PM, orally (10 mg). The level of HVA in plasma was determined before administration of haloperidol and again the next


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.