0
Article |

Metabolic Stress Produces Rapid Immunosuppression in Humans

Alan Breier, MD; Prince K. Arora, Phd; Owen M. Wolkowitz, MD; David Pickar, MD; Steven M. Paul, MD
Arch Gen Psychiatry. 1987;44(12):1108-1109. doi:10.1001/archpsyc.1987.01800240084014.
Text Size: A A A
Published online

To the Editor.—  A growing number of preclinical and clinical studies1-4 have shown that exposure to stress results in suppression of immune function. In humans, reductions in cell-mediated immunity have been associated with depression and bereavement3,4; however, the mechanisms involved in stress-induced immunosuppression are not fully understood. An experimental stress paradigm that reliably produces alterations in immune function in humans could be an important tool in helping to assess the mechanism(s) underlying stress-related immunosuppression.Our laboratory is involved in a series of studies examining the behavioral and neurobiologic effects of 2-deoxy-D-glucose (2-DG), a metabolic stressor, on normal volunteers and psychiatric patients. 2-DG is a glucose analogue that competitively inhibits glucose-6phosphate, resulting in disruption of intracellular glucose utilization. The behavioral and physiological effects of 2-DG administration include fatigue, hypothermia, increased hunger, diaphoresis, tachycardia, increased sympathetic nervous system activity, and increased cortisol secretion.5 We now report that 2-DG administration

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();