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Metabolic Stress Produces Rapid Immunosuppression in Humans

Alan Breier, MD; Prince K. Arora, Phd; Owen M. Wolkowitz, MD; David Pickar, MD; Steven M. Paul, MD
Arch Gen Psychiatry. 1987;44(12):1108-1109. doi:10.1001/archpsyc.1987.01800240084014.
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To the Editor.—  A growing number of preclinical and clinical studies1-4 have shown that exposure to stress results in suppression of immune function. In humans, reductions in cell-mediated immunity have been associated with depression and bereavement3,4; however, the mechanisms involved in stress-induced immunosuppression are not fully understood. An experimental stress paradigm that reliably produces alterations in immune function in humans could be an important tool in helping to assess the mechanism(s) underlying stress-related immunosuppression.Our laboratory is involved in a series of studies examining the behavioral and neurobiologic effects of 2-deoxy-D-glucose (2-DG), a metabolic stressor, on normal volunteers and psychiatric patients. 2-DG is a glucose analogue that competitively inhibits glucose-6phosphate, resulting in disruption of intracellular glucose utilization. The behavioral and physiological effects of 2-DG administration include fatigue, hypothermia, increased hunger, diaphoresis, tachycardia, increased sympathetic nervous system activity, and increased cortisol secretion.5 We now report that 2-DG administration


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