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Plasma Haloperidol Levels and Clinical Response

Robert C. Smith, MD, PhD
Arch Gen Psychiatry. 1987;44(12):1110-1112. doi:10.1001/archpsyc.1987.01800240086016.
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To the Editor.—  We previously reported in the Archives a study of blood haloperidol levels and clinical response in schizophrenic patients1; amplifications of this study with corrections were also published.2,3 The results with a slightly expanded sample utilizing both plasma and red blood cell haloperidol levels were reported in another journal.4 We have subse-Relationship between mean plasma haloperidol levels determined by gas-liquid chromatography and percentage decrease in Brief Psychiatric Rating Scale (BPRS) psychosis factor scores by day 24 of haloperidol treatment. Open squares indicate subjects in original samples excluding subjects chronically hospitalized in state facilities; solid squares, subjects in new sample excluding subjects chronically hospitalized in state facilities; and triangles, patients chronically hospitalized in state facilities. Line is best fit regression for all subjects excluding state hospital nonresponders (n =49). quently completed studies on a new sample


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