0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Somatostatin Immunoreactivity in Postmortem Brain From Depressed Suicides-Reply

Garth Bissette, PhD; Charles B. Nemeroff, MD, PhD
Arch Gen Psychiatry. 1988;45(6):597-598. doi:10.1001/archpsyc.1988.01800300095016.
Text Size: A A A
Published online

In Reply.—  Charlton et al have commented on the findings of our study1 and other studies2 concerning the reduction in CSF concentrations of somatostatin in patients with major depression. They add to the literature with measurements of somatostatin in different brain regions of depressed suicides and controls and find no differences between the two groups. In their comment they state that "the reported reduction of somatostatin-I concentration in CSF in depression does not appear to be a reflection of a reduced concentration of somatostatin-I in the cortex." They further indicate that the site of origin of somatostatin in CSF is unclear. Charlton et al correctly conclude that if a reduction of the somatostatin level in CSF in depression is a true reflection of pathophysiology of central somatostatin, then a reduced turnover or impaired release may be the central mechanism, rather than neuronal degeneration, as has been observed in

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();