We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Persistence of Haloperidol in the Brain

Bruce M. Cohen, MD, PhD; Suzann Babb, MS; Alexander Campbell, MPhil; Ross J. Baldessarini, MD
Arch Gen Psychiatry. 1988;45(9):879-880. doi:10.1001/archpsyc.1988.01800330113019.
Text Size: A A A
Published online


To the Editor.—  A growing body of evidence suggests that the effects of neuroleptic drugs may persist long after termination of treatment. Side effects, including the life-threatening neuroleptic malignant syndrome,1 have been reported to last for days to weeks after medication is discontinued,2,3 and clinical relapse, even in chronically ill patients, may not occur for weeks or months after administration of the drug is stopped.4 A parallel phenomenon is evident in animals: rats given single, moderate doses of haloperidol exhibited signs of central dopaminergic blockade (antagonism of apomorphine) for at least 30 days after treatment.5 It is not known whether these extended effects of neuroleptics are due to continued presence of drug in tissue or to long-lasting physiologic changes that are a consequence of exposure to drug.Plasma elimination half-lives for neuroleptics in humans and rats are reported typically to be about 24 hours.4 This


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.