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Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions

Ma-Li Wong, MD
Arch Gen Psychiatry. 1988;45(11):1054. doi:10.1001/archpsyc.1988.01800350088017.
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To the Editor.—  It is interesting to note that while the existence of dementia or cognitive deficits affecting chronic psychiatric patients is common anecdotal knowledge among psychiatrists, it has been very difficult to specify and quantify those deficits.In the November 1987 issue of the Archives, Goldberg et al1 presented data based on Wisconsin Card Sorting test (WCS) results reinforcing the hypothesis of prefrontal-type cognitive deficits in a group of chronic schizophrenics who were receiving neuroleptic drugs. Previously, Weinberger et al2,3 presented regional cerebral blood flow data as evidence of a physiologic dysfunction of dorsolateral prefrontal cortex also related to the performance on the WCS.Although the data presented by Goldberg et al1 and Weinberger et al2,3 were carefully obtained, one should always keep in mind that they studied patients with chronic conditions who had received or were receiving neuroleptic medication. Could similar data be obtained


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