Article |

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

Samuel G. Siris, MD
Arch Gen Psychiatry. 1988;45(11):1055. doi:10.1001/archpsyc.1988.01800350089019.
Text Size: A A A
Published online

To the Editor.—  In his article, published in the July 1987 issue of the Archives, Weinberger1 presents an intriguing and heuristically rich model of hypothesized interaction between prefrontal cortical and mesolimbic dopamine systems in schizophrenia. This model is consistent with a great deal of evidence that has accumulated with regard to schizophrenia, including, crucially, the timing of its onset in terms of developmental maturation within the central nervous system. Weinberger's is the latest of a series of structural versions of the "diathesis" in the stress-diathesis model of schizophrenia.2Weinberger notes that the structural lesion in such a model does not necessarily imply the existence of a distinct, discontinuous biologic subgroup. The "schizophrenia lesion" in such a model could possibly be no more than the extreme end of a developmental spectrum with regard to the organization of a particular central nervous system functional system, such as the hypothesized abnormality


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.