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Eye Tracking Dysfunction Is Associated With Partial Trisomy of Chromosome 5 and Schizophrenia

William G. Iacono, PhD; Anne S. Bassett, MD; Barry D. Jones, MD
Arch Gen Psychiatry. 1988;45(12):1140-1141. doi:10.1001/archpsyc.1988.01800360088014.
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To the Editor.—  In their recent article, Holzman et al1 showed that schizophrenia and deviant smooth-pursuit eye tracking may both be transmitted by an autosomal dominant gene. These investigators concluded from their findings that family studies in which eye tracking as well as manifest schizophrenia and related disorders are assessed may enhance the productivity of molecular genetic investigations of schizophrenia. Herein we present data from a case study that are consistent with this view.

Report of Cases.—  Recently, Bassett et al2 identified a family in which the proband and his maternal uncle had partial trisomy of chromosome 5 and schizophrenia. The proband's mother had a balanced translocation in which genetic material deleted from chromosome 5 was inserted into chromosome 1. The mother was otherwise normal, as were the proband's other firstand second-degree relatives who had normal karyotypes. These findings suggest that genes in the trisomic area of chromosome 5

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