Article |

Eye Tracking Dysfunction Is Associated With Partial Trisomy of Chromosome 5 and Schizophrenia

William G. Iacono, PhD; Anne S. Bassett, MD; Barry D. Jones, MD
Arch Gen Psychiatry. 1988;45(12):1140-1141. doi:10.1001/archpsyc.1988.01800360088014.
Text Size: A A A
Published online

To the Editor.—  In their recent article, Holzman et al1 showed that schizophrenia and deviant smooth-pursuit eye tracking may both be transmitted by an autosomal dominant gene. These investigators concluded from their findings that family studies in which eye tracking as well as manifest schizophrenia and related disorders are assessed may enhance the productivity of molecular genetic investigations of schizophrenia. Herein we present data from a case study that are consistent with this view.

Report of Cases.—  Recently, Bassett et al2 identified a family in which the proband and his maternal uncle had partial trisomy of chromosome 5 and schizophrenia. The proband's mother had a balanced translocation in which genetic material deleted from chromosome 5 was inserted into chromosome 1. The mother was otherwise normal, as were the proband's other firstand second-degree relatives who had normal karyotypes. These findings suggest that genes in the trisomic area of chromosome 5


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.