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High Rates of Chronicity and Rapidity of Relapse in Patients With Bulimia Nervosa and Depression

Martin B. Keller, MD; David B. Herzog, MD; Philip W. Lavori, PhD; Ingrid L. Ott; Isabel S. Bradburn, MEd; Elizabeth M. Mahoney
Arch Gen Psychiatry. 1989;46(5):480-481. doi:10.1001/archpsyc.1989.01810050094018.
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To the Editor.—  This report adds an additional year of follow-up to a longitudinal study on patients with bulimia nervosa and affective disorder, from six months1 to 18 months. Given the lack of prospective data in the literature on the course of bulimia nervosa, we designed this naturalistic study to assess the status of bulimia nervosa on a weekly basis and to concurrently follow the course of any other DSM-III2 Axis I disorder present at intake or that develops during follow-up.

Subjects and Methods.—  Subjects were recruited from a consecutive sample of female bulimic outpatients who sought treatment at the Massachusetts General Hospital Eating Disorders Unit (EDU), Boston. Thirty-one patients were selected and gave informed consent after the study procedures were explained. One woman dropped out of the study during intake. The mean age of the 30 subjects was 23.9 years, ranging from 15 to 54 years, and

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