Article |

Detection of Familial Schizophrenia Using a Psychometric Measure of Schizotypy

Mark F. Lenzenweger, PhD; Armand W. Loranger, PhD
Arch Gen Psychiatry. 1989;46(10):902-907. doi:10.1001/archpsyc.1989.01810100044008.
Text Size: A A A
Published online

• This study examined the lifetime expectancy (morbid risk) of schizophrenia, unipolar depression, and bipolar disorder in the first-degree relatives of 101 nonpsychotic psychiatric patients (probands) who were classified as schizotypy-positive or schizotypy-negative using a psychometric measure of schizotypy, the Perceptual Aberration Scale. The relatives of schizotypy-positive probands were significantly more likely to have been treated for schizophrenia than the relatives of schizotypy-negative probands. Morbid risk for unipolar depression or bipolar disorder among first-degree relatives did not differ between the proband groups. The results support Meehl's theory of the pathogenesis of schizophrenia and enhance the construct validity of the Perceptual Aberration Scale. The heuristic potential of a psychometric high-risk strategy in schizophrenia research is discussed and the need for replication of the present study is emphasized.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.