We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Depression in Panic Disorder and Response to Alprazolam Therapy

Robert E. Pyke, MD, PhD
Arch Gen Psychiatry. 1989;46(11):1053. doi:10.1001/archpsyc.1989.01810110095015.
Text Size: A A A
Published online


To the Editor.—  Many patients followed up for panic disorders eventually develop major depressive disorder with endogenous features,1 and therefore it is important to determine the effective therapy for patients with this complication. Lesser et al,2 in the May 1988 issue of the Archives, concluded that subjects with panic disorder and phobic avoidance responded positively to alprazolam therapy regardless of whether they had coexistent major depression.This appears to directly contradict the findings of Pyke and Kraus,1 who found the administration of alprazolam to be ineffective or even detrimental in patients with panic attacks and concurrent major depression but effective in patients with either panic disorder or agoraphobia with panic attacks in the absence of depression.In both the studies of Lesser et al2 and Pyke and Kraus,3 diagnoses were made by DSM-III criteria, rating scales were employed, a dosage of up to 10 mg of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.