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Increased Morbid Risk for Schizophrenia Related Disorders in Relatives of Schizotypal Personality Disordered Patients

Larry J. Siever, MD; Jeremy M. Silverman, PhD; Thomas B. Horvath, MD; Howard Klar, MD; Emil Coccaro, MD; Richard S. E. Keefe; Lynne Pinkham, MA; Paul Rinaldi, MA; Richard C. Mohs, PhD; Kenneth L. Davis, MD
Arch Gen Psychiatry. 1990;47(7):634-640. doi:10.1001/archpsyc.1990.01810190034005.
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• To evaluate whether probands from a clinical sample diagnosed as having DSM-III schizotypal and/or paranoid personality disorder have a familial relationship to the schizophrenia-related disorders, the morbid risk for schizophrenia-related disorders and other psychiatric disorders were evaluated in the first-degree relatives of patients with schizotypal and/or paranoid personality disorder and compared with the corresponding risk for these disorders in the first-degree relatives of patients with other non-schizophrenia-related personality disorders. The morbid risk for all schizophrenia-related disorders, and specifically for schizophrenia-related personality disorders, was significantly greater among the relatives of the probands with schizotypal and/or paranoid personality disorder than among the relatives of probands with other personality disorder. The morbid risk for other psychiatric disorders did not differ significantly between the first-degree relatives of the schizotypal/paranoid personality disorder and the other personality disorder control proband samples. These results suggest a specific familial association between schizophrenia-related disorders, particularly schizophrenia-related personality disorders, and clinically diagnosed schizotypal patients.

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