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Robert M. A. Hirschfeld, MD
Arch Gen Psychiatry. 1990;47(7):685-686. doi:10.1001/archpsyc.1990.01810190085014.
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ABSTRACT

To the Editor.—  At the Chief Editor's request, I am writing in response to the letter to the editor from Donald F. Klein, MD, regarding the article by Elkin and colleagues in the November 1989 issue of the Archives.1The aims of the NIMH Treatment of Depression Collaborative Research Program were "to test the feasibility and value of the collaborative clinical trial model... in the area of psychotherapy research and to study... the effectiveness of two specific forms of psychotherapy... for treating nonbipolar, nonpsychotic depressed outpatients."Regarding the first aim, I am sure that Dr Klein would join me in agreeing that the article clearly demonstrates the feasibility of high-quality clinical trials, including psychotherapy and pharmacotherapy.Regarding the second aim, the article describes in considerable detail the results of analyses that were carefully planned prior to examination of the data. They therefore are not biased by any knowledge of

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