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Déjà Vu in Depression Research

Harold A. Rashkis, MD, PhD
Arch Gen Psychiatry. 1990;47(7):688. doi:10.1001/archpsyc.1990.01810190088016.
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To the Editor.—  Had I been asleep for the past 30 or so years, I would have awakened with a strong sense of déjà vu on reading the National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program1 and the accompanying editorial2 that appeared in the November 1989 issue of the Archives. More or less by chance I was involved in probably the first attempt to measure the effects of psychotherapy3 as well as in the first use of analysis of variance in psychopharmacologic studies.4-6In the latter group of studies (these were with schizophrenics and did not involve psychotherapy, which would partly explain why the NIMH study did not include them in its references), we did not begin therapy until the patients had responded fully to the new research environment and had thus achieved a modest amount of cognitive restructuring.7 This initial


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