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Use of Antidepressants in Schizophrenia: Diagnostic Problems-Reply

Robert L. Spitzer, MD; Michael B. First, MD
Arch Gen Psychiatry. 1990;47(10):980. doi:10.1001/archpsyc.1990.01810220096019.
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In Reply.—  In recent years, there have been multiple sets of diagnostic criteria developed (eg, Feighner, RDC, DSM-III, and DSM-III-R) and two more are on the horizon (International Classification of Diseases, 10th Revision, and DSM-IV). Depending on a number of factors (eg, when the study was done, prior experience with the system, and desire for comparability with similar studies), the researcher will choose a diagnostic system to define the study population. Dr Osser correctly points out that the clinician who is only familiar with the current standard system (now DSM-III-R) may have great difficulty in interpreting the results of published studies that use systems with which he or she is not familiar.There are two solutions to this problem. The first would be for journals to require that all submitted papers use the current official system, or the prior official system if the study had started before the adoption of the current


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